Piroxicam for Arthritis – What You Need to Know

If you’ve tried countless pills for joint pain, you’ve probably heard of piroxicam. It’s an NSAID that many doctors prescribe for arthritis when other meds aren’t enough. Below we break down how it works, when it’s a good choice, and what to watch out for.

How Piroxicam Relieves Arthritis Pain

Piroxicam blocks the enzymes called COX‑1 and COX‑2. Those enzymes make prostaglandins, which are chemicals that cause swelling and hurt. By cutting prostaglandin production, the drug lowers inflammation and eases the ache in knees, hips, or hands.

Typical doses for adults start at 10 mg once a day, taken with food to reduce stomach upset. Some people stay on the same dose for months; others use it only during flare‑ups. The long half‑life (about 45 hours) means you don’t need to remember a strict schedule – one tablet a day usually does the trick.

Safety Tips and Common Side Effects

Like all NSAIDs, piroxicam can irritate the stomach lining. If you have a history of ulcers, talk to your doctor before starting. Taking it with a meal, milk, or an antacid can help keep the gut calm.

Watch for signs of bleeding – black stools, coughing up blood, or unusual bruising. If any of these appear, stop the medication and call a health professional right away.

Your kidneys also take a hit from long‑term NSAID use. Stay hydrated and get blood tests regularly if you’re on piroxicam for more than a few weeks. The drug isn’t the best pick if you have severe kidney disease or heart failure.

Women who are pregnant or planning to become pregnant should avoid piroxicam. It can affect the baby’s heart development, especially in the third trimester.

Some people feel a mild headache or dizziness when they first start. Those symptoms usually fade after a few days. If they linger, let your doctor know – a dosage tweak might fix it.

Mixing piroxicam with other NSAIDs, blood thinners, or certain antidepressants can raise the risk of bleeding. Always list every medication you take, even over‑the‑counter drugs, before adding piroxicam.

When used correctly, many patients report noticeable pain relief within a week. You may find you can move more easily, sleep better, and need fewer physical‑therapy sessions.

Bottom line: piroxicam is a solid option for arthritis pain if you need stronger relief than ibuprofen or naproxen. Keep an eye on stomach health, kidney function, and any warning signs. Talk openly with your doctor, follow the dosing schedule, and you’ll get the most benefit with the fewest hassles.

Clear, evidence-backed guide to piroxicam for arthritis: when to use it, dosing, risks, interactions, safety tips, and how it compares to other NSAIDs in 2025.

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